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September 1985

Muscle Prostaglandin Production in the Rat: Effect of Abdominal Sepsis and Different Amino Acid Formulations

Author Affiliations

From the Departments of Surgery (Drs Freund, Muggia-Sullam, LaFrance, and Fischer) and Nephrology (Dr Barcelli and Ms Gallon), University of Cincinnati Medical Center.

Arch Surg. 1985;120(9):1037-1038. doi:10.1001/archsurg.1985.01390330049009

• Recent in vitro studies attribute regulatory functions to prostaglandins (PGs) in muscle protein metabolism, particularly enhancing proteolysis. In the present study, the amount of muscle PG production from endogenous precursors was determined in control and septic animals (cecal ligation and puncture) that were infused with 5% dextrose or dextrose with three amino acid formulations differing in their branched-chain amino acid (BCAA) content. We could not detect any differences in prostaglandin E, 6-keto-prostaglandin F, and thromboxane B2 production between control and septic animals. Furthermore, the infusion of BCAAs, which have previously been shown to be nitrogen sparing following injury, did not influence the production of any of the PGs studied in either control or septic muscle. It is likely that the effects of the BCAAs on muscle synthesis and degradation are independent of the PGs.

(Arch Surg 1985;120:1037-1039)

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