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February 1986

Alterations in Exogenous Substrate Metabolism in Sepsis

Author Affiliations

From the Departments of Surgery, University of Pennsylvania School of Medicine, Philadelphia (Drs Fried, Bailey, Mullen, and Buzby), Philadelphia Veterans Administration Medical Center (Drs Crosby and Buzby), and the University of Medicine and Dentistry of New Jersey, Newark (Dr Stein).

Arch Surg. 1986;121(2):173-178. doi:10.1001/archsurg.1986.01400020059007

• Metabolic rates and substrate utilization patterns were evaluated by using a rate cecal ligation and perforation model. Animals that survived for 48 hours after the induction of sepsis were hypermetabolic and responded appropriately to varying exogenous substrate infusions. In contrast, animals that did not survive to 48 hours were premorbidly hypometabolic and failed to adjust their oxidation patterns in response to the exogenous substrate supply. These findings suggest the benefit of individually tailoring the supply of exogenous nutrients in critically ill patients with sepsis and of frequent reassessment of metabolic parameters, including the resting energy expenditure and respiratory quotient.

(Arch Surg 1986;121:173-178)

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