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July 1986

Antiplatelet Therapy and Vascular Grafts: Studies in a Baboon Ex Vivo Shunt

Author Affiliations

From the Departments of Surgery (Drs Eldrup-Jorgensen, Connolly, Mackey, O'Donnell, and Callow) and Radiology (Ms Ramberg), Tufts University School of Medicine and the New England Medical Center, Boston; and the Naval Blood Research Laboratory, Boston University School of Medicine (Dr Valeri).

Arch Surg. 1986;121(7):778-781. doi:10.1001/archsurg.1986.01400070044009

• Antiplatelet therapy is currently recommended in an effort to improve patency rates of small-caliber vascular grafts. The effect of aspirin and heparin on acute platelet deposition was studied in a baboon ex vivo shunt. Two grafts, expanded polytetrafluoroethylene and knitted Dacron, were exposed to a flow rate of 25 mL/min after administration of aspirin or heparin. Indium 111–labeled platelet uptake by the grafts was determined over 2½ hours. The amount of platelet deposition in the treated groups was significantly less than that of controls after 2½ hours. There was no difference between the aspirin and heparin groups. The finding that heparin inhibited platelet deposition to a degree comparable with aspirin suggests that it may not be necessary to start antiplatelet therapy preoperatively. Intraoperative systemic heparinization will provide sufficient inhibition of platelet deposition. A protocol for perioperative antiplatelet therapy is outlined.

(Arch Surg 1986;121:778-781)

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