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July 1986

Pulmonary Dysfunction Associated With Streptokinase Therapy

Author Affiliations

From the Department of Surgery, Tulane University School of Medicine, New Orleans.

Arch Surg. 1986;121(7):852-853. doi:10.1001/archsurg.1986.01400070122026

• A 66-year-old lower-extremity amputee with an acute femoral artery occlusion was treated with low-dose (10 000 units/h) percutaneous constant-infusion streptokinase. At 48 hours after initiation of therapy, the patient experienced adult respiratory distress syndrome and died. A postmortem examination confirmed the diagnosis; laboratory studies reflected an increased level of fibrinolytic split products, thrombocytopenia, and a low level of fibrinogen.

(Arch Surg 1986;121:852-853)

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