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January 1988

Pseudohyperparathyroidism Secondary to Gigantic Mammary Hypertrophy

Author Affiliations

From the Section of Gastroenterologic and General Surgery (Dr Van Heerden), the Division of Endocrinology, Metabolism, and Internal Medicine (Dr Gharib), and the Section of Plastic and Reconstructive Surgery (Dr Jackson), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Surg. 1988;123(1):80-82. doi:10.1001/archsurg.1988.01400250090016

• Pseudohyperparathyroidism encompasses both ectopic hyperparathyroidism and the more commonly encountered nonparathyroid humoral hypercalcemia of malignancy—metastatic breast cancer being the classic example. Benign breast disease is a rare cause of hypercalcemia. We recently managed a patient with gigantic mammary hypertrophy that occurred during pregnancy who concomitantly manifested marked nonparathyroid hypercalcemia. This report strongly suggests that a causal relationship exists between benign breast disease and hypercalcemia.

(Arch Surg 1988;123:80-82)