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June 1988

Prognostic Significance of DNA Ploidy and Proliferative Index in Breast Carcinoma

Arch Surg. 1988;123(6):783. doi:10.1001/archsurg.1988.01400300129028

To the Editor.—An association of DNA aneuploidy of tumor cells with poorer prognosis in patients with breast cancer has been documented. However, our recent study disclosed that aneuploidy did not worsen survival of these patients.

Patients and Methods.—We examined 135 archival specimens of breast cancer by DNA flow cytometry, using a modification of the method of Hedley et al.1 The mean (± SD) patient age was 52.2 ± 11.7 years. The stage of the disease, as determined by the TNM classification,2 was as follows: stage I in 48 patients, stage II in 57 patients, stage IIIA in 12 patients, stage IIIB in 11 patients, and stage IV in seven patients.

Results.—The DNA was diploid in 31 cases and aneuploid in 104 cases. There was no correlation between DNA ploidy and disease stage. The DNA ploidy also did not correlate with patient survival (Fig 1). The