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In Reply.—We thank Drs Miholic and Klepetko for their thoughtful comments on this difficult problem. Table 4 shows only independent prognostic variables (including total gastrectomy) that were identified by statistical analysis using the Cox model. None of the other variables, such as tumor size, appears in the table because they were rejected as insignificant by the model, after consideration of those variables found to be independently predictive of death for this population of patients. In performing our Cox model analysis, we did use all of the covariate pairs listed in Table 1, including tumor size and TNM stage. Drs Miholic and Klepetko will find this clearly stated at the bottom of Table 4. Thus, all eight clinical and pathologic factors identified as significant by univariate analysis were entered into the model, as were all other variables not so identified. The word seven was an error in our manuscript; we
SHIU MH, GODBOLD J, BRENNAN MF. Total Gastrectomy and Survival-Reply. Arch Surg. 1988;123(10):1286–1287. doi:10.1001/archsurg.1988.01400340112022