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February 1989

Partial Hepatectomy Augments the Liver's Antitumor Response

Author Affiliations

From the Departments of Surgery (Drs Doerr and Castillo) and Medicine, Division of Gastroenterology and Hepatology (Dr Cohen and Mr Evans), State University of New York at Buffalo, Buffalo General Hospital, and the Department of Cell and Tumor Biology, Roswell Park Memorial Institute (Dr Goldrosen and Mr Paolini), Buffalo.

Arch Surg. 1989;124(2):170-174. doi:10.1001/archsurg.1989.01410020040006

• Despite adequate locoregional control, colorectal metastasis to the liver remains a significant cause of death. Resection of hepatic metastasis improves five-year survival 18% to 34%. A study of the impact of 40% partial hepatectomy on cytokine production in the liver was undertaken. Nonparenchymal liver cells (NPCs) were prepared by collagenase perfusion and metrizamide gradient from partially hepatectomized and laparotomized control C57BL/6Ros mice. Nonparenchymal cell from partially hepatectomized mice compared with laparotomized mice showed a twofold to threefold increase in interferon (IFN) activity. Both interferon alpha/beta and supernatants from cultured NPCs of partially hepatectomized mice suppressed the proliferation of liver-derived MCA-38 colon adenocarcinoma cells in vitro. This tumor has been shown to metastasize to the liver of C57BL/6Ros mice. The production of various cytokines by NPCs induced by partial hepatectomy may provide a possible antimetastatic mechanism.

(Arch Surg 1989;124:170-174)

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