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June 1989

Thromboxane A2-Receptor Blockade and Prostacyclin in Porcine Escherichia coli Shock

Author Affiliations

From the Departments of Surgery (Drs Svartholm, Bergqvist, and Haglund) and Experimental Research (Drs Svartholm, Bergqvist, Hedner, and Haglund, and Ms Ljungberg), Lund University, Malmö (Sweden) General Hospital; and Research Department, Novo Industri, A/S, Bagsvaerd, Denmark (Dr Hedner).

Arch Surg. 1989;124(6):669-672. doi:10.1001/archsurg.1989.01410060031006

• Septic shock was induced by intravenous infusion of live Escherichia coli in pigs to investigate the influences on central hemodynamic, coagulation, and fibrinolytic reactions by a thromboxane A2 (T×A2)–receptor blocker (BM 13.177; n=6) and a prostacyclin analogue (iloprost or ZK 36374; n=7). The early pulmonary vasoconstriction following E coli infusion was attenuated, but not abolished, by BM 13.177. Only minor effects were seen after pretreatment with iloprost. Neither drug had any major effect on the coagulation and fibrinolytic activation. These results confirm that T×A2 is an important, but not the only, mediator of early pulmonary vascular response in porcine septicemia and that neither T×A2 nor prostacyclin is of major importance for the hemostatic reactions in this shock model.

(Arch Surg 1989;124:669-672)

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