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July 1989

Function of Pancreas Allografts More Than 1 Year Following Transplantation

Author Affiliations

From the Department of Surgery, University of Iowa College of Medicine and Transplantation Services, University of Iowa Hospitals and Clinics, Iowa City. Dr Wright is now with Parkview Medical Center, Nashville, Tenn.

Arch Surg. 1989;124(7):796-800. doi:10.1001/archsurg.1989.01410070046010

• At the University of Iowa, Iowa City, 75 pancreas transplant procedures were performed for type I diabetes mellitus from March 1984 to September 1988. Forty-seven of these transplants were performed simultaneously with kidney transplants from the same donor; 23 followed previous kidney transplants, and 5 were preuremic pancreas-only transplants. The 1-year patient survival rate is 85% and pancreas graft survival rate is 54%. The simultaneous kidney and pancreas group had a 1-year patient survival rate of 82%, a pancreas graft survival rate of 59%, and a renal graft survival rate of 73%. Thirty-one of 70 kidney and pancreas recipients had a functioning pancreas 1 year post transplantation and 26 of 31 currently have a functioning pancreas and are insulin free. Patient symptoms of neuropathy and gastroenteropathy are improved with long-term graft function. Some patients may develop type II diabetes post transplantation with impaired glucose tolerance despite high insulin production by the graft. Pancreas transplantation is the only therapy that achieves a euglycemic state as indicated by glycosylated hemoglobin and glucose tolerance testing. Centers must continue to follow up patients on a long-term basis to determine the final effects on the secondary complications of diabetes.

(Arch Surg. 1989;124:796-800)

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