• This is a report of a phase I trial of intraoperative radiation therapy in combination with intraoperative hyperthermia for the treatment of locally advanced, unresectable intra-abdominal carcinomas. Using an ultrasound transducer system specifically designed for intraoperative applications, 19 patients have been successfully treated, demonstrating the feasibility of this combination modality. The morbidity (58%) and mortality (11%) rates reported in this series are comparable to rates reported in series of similar patients receiving intraoperative radiation therapy alone. There is still a great need for considerable technological development to enable the use of intraoperative hyperthermia to treat large, complexly shaped intra-abdominal tumors, and phase II and III trials of this combination treatment modality should be performed.
(Arch Surg. 1990;125:370-375)
Colacchio TA, Coughlin C, Taylor J, Douple E, Ryan T, Crichlow RW. Intraoperative Radiation Therapy and HyperthermiaMorbidity and Mortality From This Combined Treatment Modality for Unresectable Intra-abdominal Carcinomas. Arch Surg. 1990;125(3):370–375. doi:10.1001/archsurg.1990.01410150092017