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March 1990

Intraoperative Radiation Therapy and Hyperthermia: Morbidity and Mortality From This Combined Treatment Modality for Unresectable Intra-abdominal Carcinomas

Author Affiliations

From the Department of Surgery, Dartmouth Medical School, Hanover, NH.

Arch Surg. 1990;125(3):370-375. doi:10.1001/archsurg.1990.01410150092017

• This is a report of a phase I trial of intraoperative radiation therapy in combination with intraoperative hyperthermia for the treatment of locally advanced, unresectable intra-abdominal carcinomas. Using an ultrasound transducer system specifically designed for intraoperative applications, 19 patients have been successfully treated, demonstrating the feasibility of this combination modality. The morbidity (58%) and mortality (11%) rates reported in this series are comparable to rates reported in series of similar patients receiving intraoperative radiation therapy alone. There is still a great need for considerable technological development to enable the use of intraoperative hyperthermia to treat large, complexly shaped intra-abdominal tumors, and phase II and III trials of this combination treatment modality should be performed.

(Arch Surg. 1990;125:370-375)