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March 1990

Intracellular Lipid Droplets in Functioning Transitional Parathyroid Oxyphil Adenomas: A Caveat

Author Affiliations

From the Departments of Pathology (Dr Alpern) and Surgery (Dr Olson), The Mary Imogene Bassett Hospital, Cooperstown, NY; the Departments of Pathology (Dr Alpern) and Surgery (Dr Olson), College of Physicians and Surgeons, Columbia University, New York, NY; and the Department of Pathology, Northwestern University Medical School, Chicago, Ill (Dr Roth).

Arch Surg. 1990;125(3):410-411. doi:10.1001/archsurg.1990.01410150132026

• Histochemical demonstration of intracellular lipid droplets on frozen section has been used to distinguish normal parathyroid tissue from that of adenoma and chief cell hyperplasia. Differentiation is based on the observation that the cells of adenoma and chief-cell hyperplasia largely lack intracellular lipid, which is present in the suppressed chief cells of normal glands in patients with adenoma. We present two functional transitional oxyphil adenomas that contained abundant intracellular lipid. Failure to recognize that transitional oxyphilic adenomas may contain focal accumulations of intracellular lipid droplets could lead to confusion in histologic interpretation.

(Arch Surg. 1990;125:410-411)