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July 1990

Combined Kidney and Pancreas Transplantation: A Safe and Effective Treatment for Diabetic Nephropathy

Author Affiliations

From the Transplantation Service, University Hospitals of Cleveland (Drs Schulak, Mayes, and Hricik), and the Departments of Surgery (Drs Schulak and Mayes) and Medicine (Dr Hricik), Case Western Reserve University School of Medicine, Cleveland, Ohio.

Arch Surg. 1990;125(7):881-885. doi:10.1001/archsurg.1990.01410190079012

• Seventeen patients with type I diabetes and diabetic nephropathy underwent combined kidney and pancreas transplantation. Mean age was 32±6 years and average duration of diabetes was 21 ±6 years. Transplantation was performed through bilateral iliac fossa incisions, and graft duodenocystostomy was used to achieve exocrine pancreas drainage. The actuarial patient and kidney survival rate was 92% and the pancreas survival rate, 88% (follow-up of 3 to 28 months). One patient with functioning grafts died at 10 months owing to a cardiac arrhythmia and one pancreas was "lost" to early thrombosis. Major morbidity was due to pancreas wound infection (53%) that required reoperatlon, but all patients have had subsequent healing of their wounds. Rehabilitation with return to meaningful activity has been accomplished by 15 patients. This experience demonstrates that combined kidney and pancreas transplantation can be performed safely and successfully.

(Arch Surg. 1990;125:881-885)