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September 1990

Differential Production of Interleukin 1 on the Surface of Biomaterials

Author Affiliations

From the Department of Surgery, Division of General Surgery, University of Medicine and Dentistry of New Jersey—Robert Wood Johnson Medical School, New Brunswick.

Arch Surg. 1990;125(9):1158-1160. doi:10.1001/archsurg.1990.01410210084013

• The production of cytokines on the surface of surgical biomaterials plays a major role in their biocompatibility. Membraneassociated interleukin 1 (mlL-1) is a cytokine found on the surface of macrophages activated by biomaterials. To better understand the host—foreign body interaction, we quantitated the production of mlL-1 on the surface of two materials commonly used in surgery, expanded polytef (ePTFE) and silicon elastomer (SE). The mean (± SD) level of mlL-1 produced by adherent cells to ePTFE significantly decreased from day 2 (13746 ± 3630 cpm per disk) compared with day 7(2828 ± 1304 cpm per disk). However, the level of mlL-1 produced by ePTFE-adherent cells was still markedly greater than the level of mlL-1 produced by cells adherent to SE (1877±1028vs 1595 ±822 cpm per disk). These results indicate that ePTFE and SE elicit a differential host response in terms of cytokine production. This study may enhance our understanding of the cellular events on the surface of biomaterials that underlie clinical observations.

(Arch Surg. 1990;125:1158-1160)