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February 1991

Effects of High-Dose IgG on Survival of Surgical Patients With Sepsis Scores of 20 or Greater

Author Affiliations

From the Department of Surgery and Institute of Anesthesiology, University of Pavia, Varese, Italy (Drs Dominioni, Renzo Dionigi, Chiaranda, Roberto Dionigi, Ballabio, and Sguotti); Institute of Anesthesiology, University of Bologna (Italy) (Dr Zanello); and Institute of Anesthesiology, University of Brescia (Italy) (Dr Acquarolo).

Arch Surg. 1991;126(2):236-240. doi:10.1001/archsurg.1991.01410260126018

• Sixty-two consecutive septic surgical patients receiving standard multimodal intensive care unit treatment who developed a sepsis score of 20 or greater (day 0) were randomized to receive 0.4 g/kg of either intravenous IgG (29 patients) or human albumin (controls; 33 patients), repeated on days +1 and + 5, in a prospective, double-blind, multicenter study. The two groups were similar in age, initial sepsis scores, and acute physiology and chronic health evaluation II score. A significantly lower mortality was recorded in the IgG-treated group (38%) than in controls (67%). Septic shock was the cause of death in 7% of IgG-treated patients and in 33% of controls. The results of this study indicate that high-dose IgG improves survival and decreases death from septic shock in surgical patients with a sepsis score of 20 or greater.

(Arch Surg. 1991;126:236-240)

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