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December 1991

Vascular Soft-Tissue Sarcomas: An Analysis of Tumor-Related Mortality

Author Affiliations

From the Departments of Surgery (Drs Karpeh, Caldwell, and Brennan), Epidemiology and Biostatistics (Dr Gaynor), and Pathology (Dr Hajdu), Memorial Sloan-Kettering Cancer Center, New York, NY.

Arch Surg. 1991;126(12):1474-1481. doi:10.1001/archsurg.1991.01410360044008

• Between 1982 and 1990, 69 adult patients were admitted to Memorial Sloan-Kettering Cancer Center with a diagnosis of angiosarcoma, lymphangiosarcoma, or malignant hemangiopericytoma. The existing literature regarding sarcomas focuses on individual histologic conditions or site-specific activity and includes pediatric patients, which makes estimates of survival difficult. We describe the clinical course of all vascular sarcomas, the survival without distant recurrence of patients with vascular sarcomas, and the overall survival of patients with vascular sarcomas. Using Cox's stepwise regression model, histologic characteristics of the tumors, tumor grade, tumor size, and other factors were assessed to determine their prognostic significance. Noncurative treatment and the presence of metastases were the only two factors influencing survival. Tumor grade approached significance. Disease recurrence was common among curatively treated patients (37% of such patients), and more than half of these recurrences involved distant sites. The survival of these patients depends on complete surgical resection and is independent of individual histologic characteristics of the tumor.

(Arch Surg. 1991;126:1474-1481)

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