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November 1992

Hepatic Metastasis Alters the Immune Function of Murine Liver Nonparenchymal Cells

Author Affiliations

From the Departments of Surgery (Drs Johnkoski and Doerr) and Medicine (Dr Cohen), State University of New York, Buffalo, and the Department of Medicine, Duke University, Durham, NC (Dr Tzung).

Arch Surg. 1992;127(11):1325-1329. doi:10.1001/archsurg.1992.01420110073015

• To examine the effect of a single hepatic focus of metastatic colon tumor on the immune function of liver nonparenchymal cells (NPCs) from C57Bl/6 mice, we injected 2.5×105 liver-derived murine colon adenocarcinoma (LD-MCA-38) cells beneath the liver capsule. Three weeks following injection of the tumor cells, the immune function of the NPCs was studied. The NPCs from tumor-bearing mice exhibited increased cytotoxic and proliferative activity. The NPCs from tumor-bearing mice also contained a greater percentage of CD8+ and T-cell receptor γ/δ+ liver-associated T lymphocytes. Levels of interleukin 6 and tumor necrosis factor were increased in the NPC supernatant, and interleukin 6 levels were increased in serum from tumor-bearing mice. We conclude that the presence of a single hepatic focus of metastatic tumor results in augmented immune function of murine liver NPCs.

(Arch Surg. 1992;127:1325-1329)

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