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February 1993

Single-Dose Ceftriaxone, Ornidazole, and Povidone-lodine Enema in Elective Left Colectomy: A Randomized Multicenter Controlled Trial

Author Affiliations

From the French Association for Surgical Research, Bois-Colombes, France.

Arch Surg. 1993;128(2):228-232. doi:10.1001/archsurg.1993.01420140105017

• Patients undergoing elective left colectomy for colonic carcinoma or diverticulosis (n=341) were randomly assigned to three groups. Patients in groups 1 (102 patients) and 2 (122 patients) had two 5% povidone-iodine enemas whereas those in group 3(117 patients) had saline enemas. Groups 1 and 3 received 24-hour intravenous cefotaxime sodium and metronidazole hydrochloride. Group 2 received single injections of ceftriaxone sodium (1 g) and ornidazole (1 g). Senna concentrate was administered the evening before surgery. There was no statistically significant difference found between groups 1 and 2 concerning the number of infected patients (eight vs 11), anastomotic leakages (four vs four), extra-abdominal complications (32 vs 29), or infection-related deaths (one vs zero). Despite poorer tolerance, povidone-iodine enema was more effective than saline enemas, as there were less infected patients in group 1 (8%) or groups 1+2 (8.5%) than in group 3 (13%). Single-dose ceftriaxone-ornidazole combined with povidone-iodine enemas is effective against infective complications in elective left colonic surgery for carcinoma or diverticular disease. Single-dose antibiotic prophylaxis reduces costs and work for the nursing staff.

(Arch Surg. 1992;128:228-232)

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