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December 1993

Endocrine Organ Metastases in Subjects With Lobular Carcinoma of the Breast

Arch Surg. 1993;128(12):1344-1347. doi:10.1001/archsurg.1993.01420240052009

Objective:  To define the frequency and pattern of endocrine organ metastases in patients dying of invasive lobular carcinoma.

Design:  Postmortem microscopic evaluation of the ovaries and adrenal, pituitary, thyroid, and parathyroid glands for breast cancer metastases.

Setting:  Roswell Park Cancer Institute, Buffalo, NY, between 1971 and 1990.

Subjects:  One hundred eighteen subjects who died of their cancer: 86 had infiltrating ductal carcinoma; 32, invasive lobular carcinoma.

Mean Outcome Measure:  Quantitative measurements to allow frequency determinations and statistical comparisons.

Results:  Endocrine organ metastases were found in 91% of the subjects with invasive lobular carcinoma vs 58% of subjects with infiltrating ductal carcinoma. The adrenal gland was most frequently involved. Multiple endocrine metastases were most common in the group with invasive lobular carcinoma.

Conclusions:  A relationship exists between invasive lobular carcinoma and endocrine metastases. This indicates that antemortem endocrine evaluation may subsequently improve quality-of-life treatment.(Arch Surg. 1993;128:1344-1347)