A 57-year-old woman presented with the second recurrence of a high-grade malignant fibrous histiocytoma of the right foot, following previous local resection plus curative adjuvant radiotherapy. The first recurrence of the lesion was treated by isolated limb perfusion with cisplatin; the second recurrence was treated by isolated limb perfusion with tumor necrosis factor, interferon, and melphalan. The tumor and the area that had been irradiated showed a bluish color a few hours after tumor necrosis factor perfusion. Amputation of the right foot and leg below the knee had to be performed because of severe necrosis. (Arch Surg. 1996;131:672-674)
van Ginkel RJ, Hoekstra HJ, Eggermont AMM, Pras E, Koops HS. Isolated Limb Perfusion of an Irradiated Foot With Tumor Necrosis Factor, Interferon, and Melphalan. Arch Surg. 1996;131(6):672–674. doi:10.1001/archsurg.1996.01430180098022
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: