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August 1996

Preresection Chemotherapy Improves Survival for Children With Askin Tumors

Author Affiliations

From the Departments of Surgery (Drs Sawin and Waldhausen), Orthopedic Surgery (Dr Conrad), and Pediatrics (Dr Park), Children's Hospital and Medical Center, University of Washington School of Medicine, Seattle.

Arch Surg. 1996;131(8):877-880. doi:10.1001/archsurg.1996.01430200087015

Objective:  To test whether patients with Askin tumor treated with aggressive neoadjuvant chemotherapy have a better clinical outcome.

Design:  Retrospective case series.

Setting:  Pediatric referral center.

Patients:  All children diagnosed with malignant small-cell tumors of the chest wall (Askin tumor) and treated from 1975 to September 1987 (phase 1, n=6) and from September 1987 to the present (phase 2, n=9).

Main Outcome Measures:  Survival as a function of extent of disease and response to therapy as measured by tumor volume, survival, and recurrence.

Results:  All phase 2 patients had significant reduction of tumor volume and improved survival by Kaplan-Meier estimates compared with phase 1 patients. No phase 1 patients are still alive.

Conclusion:  Patients with Askin tumor treated with aggressive preresection chemotherapy have smaller tumors to resect and improved survival.Arch Surg. 1996;131:877-880

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