Objective To perform a systematic review and meta-analysis evaluating the risk of reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality associated with laparoscopic vs open bariatric surgery at a minimum of 12 months' follow-up.
Data Sources We systematically searched the Cochrane Library, EMBASE, and MEDLINE databases through June 1, 2010, for randomized controlled trials comparing laparoscopic with open bariatric surgery.
Study Selection We included all randomized controlled trials that reported weight loss outcomes and complications at a minimum of 12 months' follow-up and had a minimum of 50 patients. We identified 6 randomized controlled trials, which randomized 510 patients.
Data Extraction Data were extracted by 2 reviewers on study design, baseline characteristics, and surgical procedure. The outcome data extracted included change in weight and body mass index and the incidence of reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality.
Data Synthesis We used random-effects models, which accounted for within-study and between-study variability, to estimate pooled risk ratios (95% CIs). Compared with open surgery, laparoscopic surgery was associated with lower risk of wound infection (relative risk [RR], 0.21; 95% CI, 0.07-0.65) and incisional hernia (RR, 0.11; 95% CI, 0.03-0.35). The risk of reoperation (RR, 1.06; 95% CI, 0.70-1.61), anastomotic leak (RR, 0.64; 95% CI, 0.14-2.95), and all-cause mortality (RR, 0.86; 95% CI, 0.22-3.28) may be similar for laparoscopic and open bariatric surgery.
Conclusion Laparoscopic surgery may be a safer treatment than open surgery for patients requiring bariatric surgery.
Morbid obesity is a serious problem in North America. Increasing by 52.0% from 2000 to 2005, the prevalence of morbid obesity (defined as body mass index, calculated as weight in kilograms divided by height in meters squared, ≥40) in the United States is estimated at 5.7%.1,2 Morbid obesity is associated with increased risk of mortality and morbidity, including arthritis, back pain, cardiovascular disease, diabetes mellitus, and hypertension.3-5
Bariatric surgery is an efficacious treatment of morbid obesity and has been shown to promote considerable weight loss and to reduce the risk of cardiovascular disease, certain cancers, and all-cause mortality.6-10 Bariatric surgery can be performed laparoscopically (via a small incision in the abdomen) or using an open procedure (ie, laparotomy). Laparoscopic bariatric surgery has been performed since 1993 and has quickly surpassed open surgery in popularity.11 Between 2004 and 2006, more than 16 000 laparoscopic gastric bypass procedures were performed compared with approximately 6000 open gastric bypass procedures in academic medical centers across the United States.12 Based on results of observational studies and small randomized controlled trials (RCTs), laparoscopic technique is thought to reduce length of hospital stay and risk of complications; however, this has not been substantiated. Because of the increasing popularity of bariatric surgery for the treatment of morbid obesity, it is important to identify the safest method.
Our objective was to pool the results of previous RCTs comparing the risk of complications associated with laparoscopic vs open bariatric surgery. Specifically, we compared the risk of reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality associated with laparoscopic vs open bariatric surgery.
Data sources and searches
We systematically searched the Cochrane Library, EMBASE, and MEDLINE databases through June 1, 2010, using the following terms: adjustable gastric banding, bariatric, bariatric surgery, biliopancreatic diversion with duodenal switch, bypass, gastric bypass, gastric pacing, gastric stimulation, gastroplasty, implantable gastric stimulation, jejunoileal bypass, ligation, obesity, Roux-en-Y, sleeve gastrectomy, vertical banded gastroplasty, and weight loss. We limited our search to RCTs involving adults and published in English. References from previous RCTs and reviews were examined for potentially relevant publications not identified in the database search.
Studies eligible for inclusion met the following criteria: (1) they randomized patients to laparoscopic vs open bariatric surgery, (2) they reported weight loss outcomes and complications (reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality), (3) they had a follow-up period of at least 12 months, and (4) they had 50 or more patients. The sample size criterion was included to minimize the effects of publication bias. All studies that did not meet these criteria were excluded.
Our study was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement for reporting systematic reviews and meta-analyses (Figure 1).13 Two reviewers (J.R. and S.M.) independently extracted data using a standardized extraction form. The rate of disagreement for extracted data was less than 5% between the 2 reviewers. Disagreements were resolved by consensus or, when necessary, by a third reviewer (M.J.E.). Data extracted included the following: patient population, type of procedure, duration of procedure, length of hospital stay, baseline characteristics (age, sex, weight, and body mass index), study design characteristics (eg, setting, number of patients per treatment arm, and length of follow-up period), and outcome data (change in weight and body mass index and the incidence of reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality).
We used the Cochrane Collaboration's tool for assessing the risk of bias,14 focusing on the following 6 criteria: (1) sequence generation; (2) allocation concealment; (3) blinding of participants, personnel, and outcome assessors; (4) incomplete outcome data; (5) selective outcome reporting; and (6) other sources of bias. Each RCT was classified as “high quality,” “low quality,” or “unclear quality” for each criterion.
Data synthesis and meta-analysis
We used random-effects models by DerSimonian and Laird,15 which accounted for within-study and between-study variability, to estimate pooled risk ratios (95% CIs). Forest plots were created for each outcome. We used a 0.5 continuity correction for trials with no events in one or both treatment groups. We calculated I2 statistics to estimate the proportion of overall variation that was attributable to between-trial heterogeneity. We assessed for publication bias using the modified test for small-study effects by Harbord et al.16 For data handling and statistical analyses, we used commercially available software (Excel 200717 [Microsoft Corporation, Redmond, Washington] and STATA 9.018 [StataCorp LP, College Station, Texas]).
Search findings and study inclusion
Our literature search identified 2446 potentially relevant studies (Figure 1); 159 were retrieved for full-text assessment, and 6 met our inclusion criteria. The remaining 153 studies were excluded for the following reasons: (1) they were not an RCT (n = 94), (2) they did not compare laparoscopic with open bariatric surgery (n = 40), (3) they did not include outcomes relevant to our study (n = 10), (4) they did not include a comparison group (n = 7), (5) the total sample size was fewer than 50 patients (n = 1), or (6) the follow-up period was less than 12 months (n = 1). The RCT19 excluded for having fewer than 50 patients did not report enough relevant outcomes to warrant inclusion.
The risk of bias was unknown for many included RCTs (Figure 2). Specifically, 3 RCTs20-22 did not report sequence generation, and 4 RCTs20-23 did not report allocation concealment. Only 1 RCT21 blinded the participants to their treatment group, and none mentioned whether outcome assessors were blinded.20-25 Two RCTs21,25 did not provide the number of patients at follow-up periods, and 1 RCT25 reported weight loss outcomes in a figure; therefore, the risk of incomplete outcome data was unknown. Finally, 2 RCTs20,21 used blocked randomization with fixed block sizes in an unblinded trial, and 1 study22 had an unbalanced prevalence of comorbidity between the treatment groups; these RCTs were classified as having a high risk of other sources of bias. Using the modified test for small-study effects by Harbord et al,16 our results suggest that there was no publication bias among the RCTs in our meta-analysis for reoperation (P = .18), wound infection (P = .95), incisional hernia (P = .22), or anastomotic leak (P = .99).
Reported baseline data were similar across laparoscopic and open bariatric surgery groups (Table 1). The mean age ranged from 37 to 42 years, and the percentage of female patients ranged from 68% to 92%. All patients were considered to have morbid obesity. The mean weight at baseline, reported in 3 RCTs, ranged from 130.7 to 152.2 kg. The mean body mass index at baseline ranged from 41 to 52.
Study design and operative characteristics
The 6 included RCTs randomized a total of 262 patients to laparoscopic bariatric surgery and 248 patients to open bariatric surgery (Table 2). Follow-up periods ranged from 12 to 24 months. Four RCTs reported the prevalence of loss to follow-up, which ranged from 0.0% to 2.0%. Operative time ranged from 150 to 245 minutes in the laparoscopic group and from 76 to 202 minutes in the open group. The mean length of hospital stay ranged from 3 to 6 days in the laparoscopic group and from 4 to 8 days in the open group, suggesting that laparoscopic surgery was associated with, on average, a reduction of 1 to 3 days in the hospital. We were unable to pool the data on length of hospital stay because only 2 studies reported standard deviations.
Complications reported for each RCT include reoperation, wound infection, incisional hernia, anastomotic leak, and all-cause mortality (Table 3). The number of patients who required reoperation ranged from 1 to 20 patients in the laparoscopic group and from 0 to 21 patients in the open group. The risk of reoperation was similar in the 2 groups (relative risk [RR] of laparoscopic vs open surgery, 1.06; 95% CI, 0.70-1.61), albeit with a wide 95% CI (Figure 3). Most RCTs included in our meta-analysis reported anastomotic leak (4 studies) and intestinal obstruction (3 studies) as reasons for reoperation (Table 4). The incidence of wound infection ranged from 0 to 1 in the laparoscopic group vs 1 to 8 in the open group. The risk of wound infection was substantially lower in the laparoscopic group (RR, 0.21; 95% CI, 0.07-0.65) (Figure 4). The incidence of incisional hernia was 0 in the laparoscopic group and ranged from 1 to 10 in the open group. The risk of incisional hernia was substantially lower in the laparoscopic group (RR, 0.11; 95% CI, 0.03-0.35) (Figure 5). The incidence of anastomotic leak ranged from 0 to 2 in the laparoscopic group and from 0 to 3 in the open group. The risk of anastomotic leak was lower in the laparoscopic group (RR, 0.64; 95% CI, 0.14-2.95); however, the 95% CI was wide (Figure 6). Finally, the incidence of all-cause mortality ranged from 0 to 2 in the laparoscopic group and from 0 to 2 in the open group. Although the point estimate suggested that the risk of all-cause mortality was similar for both groups, the result is debatable because of the wide 95% CI (RR, 0.86; 95% CI, 0.22-3.28) (Figure 7).
Weight loss outcomes at 12 months' follow-up were reported in 5 of 6 RCTs (Table 5). Four RCTs reported the mean change in body mass index, which ranged from −11.6 to −15.0 in the laparoscopic group and from −10.6 to −15.5 in the open group. Two RCTs reported the mean weight loss in kilograms, which ranged from −35.0 to −39.0 kg in the laparoscopic group and from −34.4 to −41.0 kg in the open group. Only 1 study25 reported the mean (SD) percentage change in excess body weight, which was −68% (−15%) for the laparoscopic group and −62% (−14%) for the open group.
Several review articles26-28 have examined laparoscopic and open bariatric surgery. A Cochrane Collaboration study26 published in 2009 reviewed data on mortality, reoperation, complications, and weight loss; however, this study did not statistically pool data to provide comparative treatment effects. Two other articles27,28 reviewed data from observational studies and RCTs examining complications and found that rates of wound infection and incisional hernia were lower with laparoscopic surgery, whereas the rate of small-bowel obstruction was higher with laparoscopic surgery. Most important, these reviews did not directly compare laparoscopic and open bariatric surgical procedures, and no comparative treatment effects were available.
Two previous meta-analyses29,30 examined laparoscopic and open bariatric surgery. Buchwald et al29 showed that the absolute risk of mortality was low, similar to that reported herein. Maggard et al30 pooled data on weight loss, complications, and mortality for laparoscopic and open bariatric surgery groups. The risks of wound infection and incisional hernia were lower in the laparoscopic group compared with the open group. However, this meta-analysis included observational and RCT data, complicating interpretation of their results. Our study provides evidence based exclusively on RCTs to avoid the possible selection bias associated with observational studies.
Our study was designed to compare the risk of complications associated with laparoscopic vs open bariatric surgery. We found that laparoscopic surgery lowered the risk of wound infection by 79% and the risk of incisional hernia by 89% compared with open surgery. The risks of reoperation, anastomotic leak, and all-cause mortality were similar for the 2 types of surgery. Too few investigations have been conducted to conclude that there is no difference in the risk of these complications; therefore, additional studies may be necessary. We were unable to pool weight loss data at 12 months' follow-up because of the heterogeneous reporting. However, RCTs reporting weight loss showed no clinically important difference between laparoscopic and open surgery. Our results suggest that laparoscopic surgery is the operation of choice for patients undergoing bariatric surgery because it reduces the risk of wound infection and incisional hernia. However, we were unable to include in our study other important complications, such as pulmonary findings, small-bowel obstruction, hemorrhage, and gastrointestinal tract results.
Because laparoscopic bariatric surgery is characterized by smaller incisions, reducing the healing time and exposure to microorganisms, it is not surprising that it is associated with a lower risk of wound infection and incisional hernia compared with open surgery. Observational cohort studies12,31-37 have corroborated this hypothesis. Given the inherent limitations of observational studies, such as potential selection bias, confounding, and investigator bias, it was necessary to evaluate the risk of these complications in RCTs. The sample sizes of the individual RCTs included in our meta-analysis were too small to provide reliable conclusions about the safety of laparoscopic vs open bariatric surgery. By pooling data across RCTs, we obtained more precise 95% CIs. Hence, we showed a decrease in the risk of wound infection and incisional hernia among patients undergoing laparoscopic bariatric surgery compared with those undergoing open bariatric surgery.
The risk of reoperation was similar in the laparoscopic and open surgery groups. However, given the wide 95% CIs and the few studies reporting reoperation in our meta-analysis, more studies may be needed to confirm this. Previous observational studies36,37 found no difference in the risk of reoperation between laparoscopic and open bariatric surgery. In contrast, a cross-sectional study38 of more than 19 000 patients undergoing bariatric surgery in 2005 found increased reoperation in the open surgery group compared with the laparoscopic surgery group (odds ratio [OR], 3.71; 95% CI, 2.47-5.59). Hence, a difference in the risk of reoperation between laparoscopic and open bariatric surgery remains debatable. The information available herein and in the literature about anastomotic leak is inconclusive.31,33,35,36 However, the risk of anastomotic leak decreases as bariatric surgeons gain more experience.31 Although no firm conclusions can be drawn, our results suggest that laparoscopic and open bariatric surgical procedures are associated with a similar risk of anastomotic leak.
Our findings indicate that bariatric surgery is a safe method of weight loss, as there was little mortality associated with laparoscopic and open procedures among a low-risk young population. Previous high-quality trials6-8,39 have illustrated the potential benefits of obesity surgery. The improvements gained with bariatric surgery far outweigh the small risk of mortality associated with the procedure.
We were unable to pool the weight loss data at 12 months' follow-up because of a large variability in the types of weight loss outcomes reported. Four RCTs reported the mean change in body mass index, which was the most common weight loss outcome reported, but only 1 RCT provided the standard deviation. Furthermore, 12-month weight loss data may be too short to be indicative of end results for bariatric surgery. The included RCTs did not report long-term weight loss data; therefore, additional RCTs may be necessary.
Our meta-analysis has several potential limitations. First, because of the limited number of RCTs comparing laparoscopic with open bariatric surgery, our meta-analysis did not have sufficient precision to conclusively compare the effects of laparoscopic and open surgery on the risks of reoperation, anastomotic leak, or all-cause mortality. Second, owing to heterogeneous reporting, we were unable to pool weight loss data. A standard weight loss outcome is necessary to effectively compare weight loss between these surgical procedures. Furthermore, additional RCTs with longer follow-up data are needed to provide meaningful weight loss outcomes for bariatric surgery. Third, owing to inconsistent reporting of complications, we were unable to address the risk associated with other complications (eg, pulmonary findings, cardiovascular events, bowel obstructions, hemorrhage, or gastrointestinal symptoms). More information on these complications is required to provide a more complete comparison of laparoscopic and open bariatric surgery. Fourth, as is true for most systematic reviews and meta-analyses, our meta-analysis may have been affected by publication bias. However, we assessed for publication bias using the modified test for small-study effects by Harbord et al16 and found no effect. Fifth, one of our included RCTs used a hand-assisted laparoscopic technique. The hand-assisted technique makes use of a larger incision than traditional laparoscopic surgery, and it may not be appropriate to pool these techniques. However, a previous prospective study40 of 272 patients compared hand-assisted with laparoscopic gastric bypass and found no difference in the risk of complications. Therefore, we included the hand-assisted technique in the laparoscopic bariatric surgery group.
In conclusion, although data from RCTs are limited, our meta -analysis demonstrates that laparoscopic bariatric surgery is associated with a substantially lower risk of wound infection and incisional hernia compared with open bariatric surgery. The differences between laparoscopic and open bariatric surgery with regard to the risks of reoperation, anastomotic leak, and all-cause mortality remain unknown. However, the risk of all-cause mortality is low in both groups among this young population. Weight loss may be similar between the 2 groups at 12 months. Further research using a standardized method of reporting weight loss and a longer follow-up period is needed to conclusively determine the most efficacious technique for bariatric surgery. Given the current information, we believe that laparoscopic and open bariatric surgical procedures are safe, but laparoscopic bariatric surgery seems to be the technique of choice.
Correspondence: Mark J. Eisenberg, MD, MPH, Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, McGill University, 3755 Côte Ste-Catherine Rd, Ste H-421.1, Montreal, QC H3T 1E2, Canada (mark.eisenberg@mcgill.ca).
Accepted for Publication: February 20, 2011.
Author Contributions:Study concept and design: Reoch, Mottillo, Filion, and Eisenberg. Acquisition of data: Reoch, Mottillo, and Shimony. Analysis and interpretation of data: Reoch, Mottillo, Shimony, Filion, Joseph, Poirier, and Eisenberg. Drafting of the manuscript: Reoch, Mottillo, Shimony, and Joseph. Critical revision of the manuscript for important intellectual content: Reoch, Mottillo, Shimony, Filion, Christou, Poirier, and Eisenberg. Statistical analysis: Mottillo, Shimony, and Joseph. Obtained funding: Mottillo, Filion, and Eisenberg. Administrative, technical, and material support: Mottillo, Poirier, and Eisenberg. Study supervision: Mottillo, Christou, and Eisenberg.
Financial Disclosure: None reported.
Funding/Support: This study was supported by grant 103506 from the Canadian Institutes of Health Research (CIHR). Ms Reoch is the recipient of a CIHR Health Professional Student Research Award. Dr Filion is supported in part by postdoctoral fellowships from the Heart and Stroke Foundation of Canada and the Fonds de la Recherche en Santé du Québec (FRSQ). Drs Joseph and Eisenberg are supported by the FRSQ Chercheur-National. Dr Poirier is an FRSQ Senior Physician-Scientist.
Previous Presentation: The abstract of this study was presented at McGill Cardiovascular Research Day; February 17, 2011; Montreal, Quebec, Canada; and the L. D. MacLean General Surgery Research Day; April 6, 2011; Montreal.
Additional Contributions: Tara Dourian, BA, assisted in data extraction.
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