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1.
Pories  WJFlickinger  EGMeelheim  DVan Rij  AMThomas  FT The effectiveness of gastric bypass over gastric partition in morbid obesity.  Ann Surg. 1982;196389- 399Google ScholarCrossref
2.
Naslund  IWickbom  GChristofferson  EAgren  G A prospective randomized comparison of gastric bypass and gastroplasty: complications and early results.  Acta Chir Scand. 1986;152681- 689Google Scholar
3.
Sugerman  HJStarkey  JBirkenhauer  R A randomized prospective trial of gastric bypass versus vertical banded gastroplasty for morbid obesity and their effects on sweets versus non-sweets eaters.  Ann Surg. 1987;205613- 624Google ScholarCrossref
4.
Hall  JCWatts  JMO'Brien  PE  et al.  Gastric surgery for morbid obesity: the Adelaide Study.  Ann Surg. 1990;211419- 427Google ScholarCrossref
5.
MacLean  LDRhode  BMSapalis  JForse  RA Results of the surgical treatment of obesity.  Am J Surg. 1993;165155- 162Google ScholarCrossref
6.
Brolin  REGorman  RCMilgrim  LMKenler  HA Multivitamin prophylaxis in prevention of post-gastric bypass vitamin and mineral deficiencies.  Int J Obes. 1991;15661- 668Google Scholar
7.
Brolin  REKenler  HAGorman  RCCody  RP The dilemma of outcome assessment after operations for morbid obesity.  Surgery. 1989;105337- 346Google Scholar
8.
Brolin  REKenler  HAGorman  JHCody  RP Long-limb gastric bypass in the super-obese: a prospective randomized study.  Ann Surg. 1992;215387- 395Google ScholarCrossref
9.
Burns  DLMascioli  EABistrian  BR Parenteral iron dextran therapy: a review.  Nutrition. 1995;11163- 168Google Scholar
10.
Mason  EEIto  CC Gastric bypass in obesity.  Surg Clin North Am. 1967;471345- 1354Google Scholar
11.
Behrns  KESmith  CDSarr  MG Prospective evaluation of gastric acid secretion and cobalamine absorption following gastric bypass for clinically severe obesity.  Dig Dis Sci. 1994;39315- 320Google ScholarCrossref
12.
Avinoah  EOvnat  ACharuzi  I Nutritional status seven years after Roux-en-Y gastric bypass surgery.  Surgery. 1992;111137- 142Google Scholar
13.
Kumpf  VJ Parenteral iron supplementation.  Nutr Clin Pract. 1996;11139- 146Google ScholarCrossref
Original Article
July 1998

Prophylactic Iron Supplementation After Roux-en-Y Gastric Bypass: A Prospective, Double-blind, Randomized Study

Author Affiliations

From the Departments of Surgery (Drs Brolin, Petschenik, and Kenler and Ms Bradley) and Environmental and Community Medicine (Dr Cody), University of Medicine and Dentistry of New Jersey[[ndash]]Robert Wood Johnson Medical School, New Brunswick; and the Department of Surgery, University of Pennsylvania, Philadelphia (Drs J. Gorman and R. Gorman).

Arch Surg. 1998;133(7):740-744. doi:10.1001/archsurg.133.7.740
Abstract

Objective  To determine whether prophylactic oral iron supplements (320 mg twice daily) would protect women from iron deficiency and anemia after Roux-en-Y gastric bypass.

Design  Prospective, double-blind, randomized study in which 29 patients received oral iron and 27 patients received a placebo beginning 1 month after Roux-en-Y gastric bypass.

Setting  Tertiary care medical center.

Patients and Interventions  Complete blood cell count and serum levels of iron, total iron binding capacity, ferritin, vitamin B12, and folate were determined preoperatively and at 6-month intervals postoperatively in 56 menstruating women who had Roux-en-Y gastric bypass.

Main Outcome Measure  Incidence of iron deficiency and other hematological abnormalities in each treatment group.

Results  Hemoglobin, hematocrit, and vitamin B12 levels were significantly decreased compared with preoperative values in both groups. Conversely, folate levels increased significantly over time in both groups. Oral iron consistently prevented development of iron deficiency in the iron group. Ferritin levels did not change significantly in the iron group. However, in placebo-treated patients, ferritin levels 2 years postoperatively were significantly decreased compared with preoperative levels. There was no difference in the incidence of anemia between the 2 groups. However, the incidence of microcytosis was substantially greater (P=.07) in placebo-treated than iron-treated patients.

Conclusions  Prophylactic oral iron supplements successfully prevented iron deficiency in menstruating women after Roux-en-Y gastric bypass but did not consistently protect these women from developing anemia. On the basis of these results we now routinely recommend prophylactic iron supplements to menstruating women who have Roux-en-Y gastric bypass.

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