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The significance of early tumor cell dissemination in colon cancer is unclear. In this prospective study of 122 patients with nonmetastasized colon cancer, Weixler et al investigated the correlation of tumor cell dissemination with bone marrow and sentinel lymph nodes. They found that tumor cell dissemination and bone marrow and sentinel lymph nodes are independent events that are associated with a worse prognosis.
The ongoing opioid epidemic necessitates the exploration of opioid prescription practices for trauma patients to formulate evidence-based prescription guidelines. In this population-based analysis of 33 762 patients who experienced trauma, Chaudhary et al examined the incidence and predictors of opioid prescription at discharge. The incidence of opioid prescription closely matched that of moderate to severe pain among patients with a traumatic injury, signifying appropriate prescription practices.
Highlights. JAMA Surg. 2017;152(10):901. doi:10.1001/jamasurg.2016.3452
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