Population-Level Symptom Assessment Following Pancreaticoduodenectomy for Adenocarcinoma | Gastroenterology | JAMA Surgery | JAMA Network
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    Original Investigation
    September 4, 2019

    Population-Level Symptom Assessment Following Pancreaticoduodenectomy for Adenocarcinoma

    Author Affiliations
    • 1Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    • 2Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • 3Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    • 4Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    • 5Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    • 6Department of General Surgery, Mansoura University, Mansoura, Egypt
    • 7Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • 8Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    JAMA Surg. 2019;154(11):e193348. doi:10.1001/jamasurg.2019.3348
    Key Points

    Question  What is the symptom burden of patients with pancreatic adenocarcinoma in the first year following resection?

    Findings  In this population-based cohort study of 615 patients with pancreatic adenocarcinoma, we demonstrate that clinically significant symptoms are prevalent following resection, but these symptoms improve in the first 3 months following surgery and certain patient factors are associated with an increased risk of symptom reporting.

    Meaning  Targeted interventions should be designed to preemptively address symptom burden for at-risk patient groups.


    Importance  Postoperative morbidity associated with pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PA) remains as high as 70%. However, to our knowledge, few studies have examined quality of life in this patient population.

    Objective  To identify symptom burden and trajectories and factors associated with high symptom burden following PD for PA.

    Design, Setting, and Participants  This population-based cohort study of patients undergoing PD for PA diagnosed between 2009 and 2015 linked population-level administrative health care data to routinely prospectively collected Edmonton Symptom Assessment System (ESAS) scores from 2009 to 2015, with a data analysis undertaken in 2018.

    Exposures  Baseline characteristics, including age, sex, income quintile, rurality, immigration status, and comorbidity burden, as well as treatment characteristics, including year of surgery and receipt of chemotherapy.

    Main Outcome and Measures  The outcome of interest was moderate to severe symptoms (defined as ESAS ≥4) for anxiety, depression, drowsiness, lack of appetite, nausea, pain, shortness of breath, tiredness, and impaired well-being. The monthly prevalence of moderate to severe symptoms was presented graphically for each symptom. Multivariable regression models identified factors associated with the reporting of moderate to severe symptoms.

    Results  We analyzed 6058 individual symptom assessments among 615 patients with PA who underwent resection (285 women [46.3%]) with ESAS data. Tiredness (443 [72%]), impaired well-being (418 [68%]), and lack of appetite (400 [65%]) were most commonly reported as moderate to severe. The proportion of patients with moderate to severe symptoms was highest immediately after surgery (range, 14%-66% per symptom) and decreased over time, stabilizing around 3 months (range, 8%-42% per symptom). Female sex, higher comorbidity, and lower income were associated with a higher risk of reporting moderate to severe symptoms. Receipt of adjuvant chemotherapy was not associated with the risk of moderate to severe symptoms.

    Conclusions and Relevance  There is a high prevalence of symptoms following PD for PA, with improvement over the first 3 months following surgery. In what to our knowledge is the largest cohort reporting on symptom burden for this population, we have identified factors associated with symptom severity. These findings will aid in managing patients’ perioperative expectations and designing strategies to improve targeted symptom management.