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Answer: Perforated Schistosomal Appendicitis
This patient had schistosomal appendicitis. Appendiceal cryptosporidiosis has been reported in 1 case of a man who was human immunodeficiency virus positive and presenting with signs and symptoms of appendicitis.1He was later found to have well-developed cryptosporidiosis. In any elderly patient presenting with signs and symptoms of appendicitis, the diagnosis of cancer must be considered. A recent article2showed that 24% of patients aged 60 years or older had appendiceal cancer when presenting with signs and symptoms of acute appendicitis.
Schistosomiasis affects approximately 200 million people in 74 countries. Most affected people reside in sub-Saharan Africa where Schistosoma mansoni, Schistosoma haematobium,and Schistosoma intercalatumare endemic. Schistosoma mansoniis endemic in parts of South America and the Caribbean. Schistosoma japonicumis endemic in China, the Philippines, and Indonesia.3The life cycle involves skin penetration by cercariae that become schistosomula and migrate to the lung and then to the liver. The larvae mature in the liver and migrate to vessels of the bowel and bladder to lay eggs. Eggs are then retained in tissue or excreted in feces or urine. Diagnosis is confirmed by detecting eggs in urine or feces. Schistosoma mansoni and S japonicumaccumulate eggs in the liver and intestine, whereas S haematobiumaccumulates eggs in the genitourinary system. Current treatment is 2 to 3 doses of praziquantel received 8 hours apart. Alternatives to praziquantel are oxamniquine and metrifonate. Reexamination of feces is performed 1 month later to assess treatment efficacy.4
Schistosomal appendicitis was first described by Turner in 1909.5The incidence has been reported to be from 0.175% to 2% in endemic areas.6-8The cause has been described as from 1 of 2 mechanisms. The first mechanism is schistosomal obstructive acute appendicitis believed to be a result of fibrosis around eggs leading to obstruction. This mechanism presents pathologically with no tissue eosinophils and granulomas seen more in the late stages of infection. The second mechanism is schistosomal granulomatous acute appendicitis believed to be a result of immunological granulomatous reactions to newly deposited eggs. This mechanism presents pathologically with tissue necrosis and eosinophilia seen more in the early stages of infection.7Appendiceal schistosomiasis is also described and can be a precursor lesion of schistosomal appendicitis.7,9
Most case reports and reviews have described S haematobiumas the pathogen responsible for schistosomal appendicitis. Currently, an obstetric case from Maryland, 3 cases from Marseilles, France, 22 cases in a large review from Hong Kong, China, and 1 case from Hong Kong have reported S japonicumas the pathogen for schistosomal appendicitis.6,10-12In our case, the patient had schistosomal obstructive acute appendicitis as evidenced by the lack of granulomas and tissue eosinophils. He also likely had schistosomiasis chronically, further correlating with schistosomal obstructive acute appendicitis. The pathogen is S japonicum, which is to be expected given that the patient is from an area where S japonicumrather than S haematobiumis endemic.
Although schistosomal appendicitis and appendiceal schistosomiasis are rare, it is becoming more common to encounter them in patients who have resided in or traveled to the endemic areas. Therefore, it is important that this diagnosis be considered especially in follow-up with appropriate antimicrobial therapy to eradicate the parasite.
Correspondence:Sonia Ramamoorthy, MD, Department of Surgery, University of California, San Diego, Medical Center, 402 Dickenson Dr, Suite 260, San Diego, CA 92103 (firstname.lastname@example.org).
Accepted for Publication: April 25, 2006.
Author Contributions:Study concept and design: Garg, Bakhtar, and Ramamoorthy. Acquisition of data: Garg, Bakhtar, and Ramamoorthy. Analysis and interpretation of data: Garg, Bakhtar, and Ramamoorthy. Drafting of the manuscript: Garg, Bakhtar, and Ramamoorthy. Critical revision of the manuscript for important intellectual content: Garg, Bakhtar, and Ramamoorthy. Administrative, technical, and material support: Ramamoorthy. Study supervision: Ramamoorthy.
Financial Disclosure:None reported.
Image of the Month—Diagnosis. Arch Surg. 2007;142(5):488. doi:10.1001/archsurg.142.5.488
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