Evaluation of the Role of Magnetic Resonance Spectroscopy in the Diagnosis of Follicular Malignancies of Thyroid | Endocrine Surgery | JAMA Surgery | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Siperstein  AEClark  OH Surgical therapy in thyroid nodules.  In: Braverman  LEUtiger  RDIngbar  SDWerner  SC eds.  The Thyroid.7th ed. Philadelphia, PA: Lippincott-Raven; 1996:917Google Scholar
Mazzaferri  EL Thyroid cancer in thyroid nodules: finding a needle in the haystack.  Am J Med 1992;93 (4) 359- 362PubMedGoogle ScholarCrossref
Vogt  TJ Hypopharynx, larynx, thyroid and parathyroid.  In:Stark  DDBradley  WG eds.  Magnetic Resonance Imaging.2nd ed. St Louis, mo : CV Mosby; 1992:12101218Google Scholar
Okada  THarada  MMatsuzaki  KNishitani  HAono  T Evaluation of female intrapelvic tumors by clinical proton MR spectroscopy.  J Magn Reson Imaging 2001;13 (6) 912- 917PubMedGoogle ScholarCrossref
Thomas  MABinesh  NYue  KDeBruhl  N Volume-localized two-dimensional correlated magnetic resonance spectroscopy of human breast cancer.  J Magn Reson Imaging 2001;14 (2) 181- 186PubMedGoogle ScholarCrossref
Hahn  PSmith  ICLeboldus  LLittman  CSomorjai  RLBezabeh  T The classification of benign and malignant human prostate tissue by multivariate analysis of 1H magnetic resonance spectra.  Cancer Res 1997;57 (16) 3398- 3401PubMedGoogle Scholar
Gupta  NKakar  AKChowdhury  VGulati  PShankar  LRVindal  A Magnetic resonance spectroscopy as a diagnostic modality for carcinoma thyroid.  Eur J Radiol 2007;64 (3) 414- 418PubMedGoogle ScholarCrossref
Krukowski  ZH  The thyroid gland and the thyroglossal tract.  InRussel  RCGWilliams  NSBulstrode  CJHeds.  Bailey and Love's Short Practice of Surgery.23rd ed. London England: Arnold;2000: 707Google Scholar
Belfiore  ALa Rosa  GLLa Porta  GA  et al.  Cancer risk in patients with cold thyroid nodules: relevance of iodine intake, sex, age, and multinodularity.  Am J Med 1992;93 (4) 363- 369PubMedGoogle ScholarCrossref
LiVolsi  VAAsa  SL The demise of follicular carcinoma of the thyroid gland.  Thyroid 1994;4 (2) 233- 236PubMedGoogle ScholarCrossref
DeMay  RM Follicular lesions of the thyroid: W(h)ither follicular carcinoma?  Am J Clin Pathol 2000;114 (5) 681- 683PubMedGoogle ScholarCrossref
Yamashina  M Follicular neoplasms of the thyroid: total circumferential evaluation of the fibrous capsule.  Am J Surg Pathol 1992;16 (4) 392- 400PubMedGoogle ScholarCrossref
Matson  GBWeiner  MW Spectroscopy.  In: Stark  DDBradley  WG eds.  Magnetic Resonance Imaging.2nd ed. St Louis, MO : CV Mosby; 1992: 438478Google Scholar
Damadian  R Tumor detection by nuclear magnetic resonance.  Science 1971;171 (976) 1151- 1153PubMedGoogle ScholarCrossref
Russell  PLean  CLDelbridge  LMay  GLDowd  SMountford  CE Proton magnetic resonance and human thyroid neoplasia I: discrimination between benign and malignant neoplasms.  Am J Med 1994;96 (4) 383- 388PubMedGoogle ScholarCrossref
Lean  CLDelbridge  LRussell  P  et al.  Diagnosis of follicular thyroid lesions by proton magnetic resonance on fine needle biopsy.  J Clin Endocrinol Metab 1995;80 (4) 1306- 1311PubMedGoogle Scholar
Yoshioka  YSasaki  JYamamoto  MSaitoh  KNakaya  SKubokawa  M Quantitation by (1)H-NMR of dolichol, cholesterol and choline-containing lipids in extracts of normal and phathological thyroid tissue.  NMR Biomed 2000;13 (7) 377- 383PubMedGoogle ScholarCrossref
Bartella  LMorris  EADershaw  DD  et al.  Proton MR spectroscopy with choline peak as malignancy marker improves positive predictive value for breast cancer diagnosis: preliminary study.  Radiology 2006;239 (3) 686- 692PubMedGoogle ScholarCrossref
Baek  HMChen  JHYu  HJMehta  RNalcioglu  OSu  MY Detection of choline signal in human breast lesions with chemical-shift imaging.  J Magn Reson Imaging 2008;27 (5) 1114- 1121PubMedGoogle ScholarCrossref
Original Article
February 2011February 21, 2011

Evaluation of the Role of Magnetic Resonance Spectroscopy in the Diagnosis of Follicular Malignancies of Thyroid

Author Affiliations

Author Affiliations: Departments of Surgery (Dr Gupta and Mr Kakar), Radio Diagnosis (Dr Chowdhury), and Biochemistry (Dr Goswami), Maulana Azad Medical College and associated Lok Nayak and Govind Ballabh Pant Hospitals, New Delhi; and the Thyroid Division, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi (Dr RaviShankar), India.

Arch Surg. 2011;146(2):179-182. doi:10.1001/archsurg.2010.345

Objectives  To evaluate role of magnetic resonance spectroscopy in differentiating benign from malignant follicular nodules.

Design  Prospective study.

Setting  Department of Surgery in collaboration with Department of Radio Diagnosis, Maulana Azad Medical College, Delhi, India.

Patients  Twenty-five patients with a solitary thyroid nodule with follicular etiology.

Interventions  Magnetic resonance spectroscopy was carried out in all the cases, and its findings were compared with the final diagnosis based on histopathological examination of sample obtained at surgery.

Main Outcome Measures  Choline peak detected on MRS.

Results  There were 17 benign cases, 16 follicular adenomas, and 1 colloid goiter. Of the 17 benign cases, only 1 showed choline peak; however, all 8 follicular carcinoma cases showed prominent choline peak. Hence, the sensitivity is 100% while the specificity is 94.11%.

Conclusion  Magnetic resonance spectroscopy may prove to be a sensitive diagnostic tool in differentiating follicular adenomas from carcinomas.