Evaluation of the Role of Magnetic Resonance Spectroscopy in the Diagnosis of Follicular Malignancies of Thyroid | Endocrine Surgery | JAMA Surgery | JAMA Network
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Original Article
February 2011February 21, 2011

Evaluation of the Role of Magnetic Resonance Spectroscopy in the Diagnosis of Follicular Malignancies of Thyroid

Author Affiliations

Author Affiliations: Departments of Surgery (Dr Gupta and Mr Kakar), Radio Diagnosis (Dr Chowdhury), and Biochemistry (Dr Goswami), Maulana Azad Medical College and associated Lok Nayak and Govind Ballabh Pant Hospitals, New Delhi; and the Thyroid Division, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi (Dr RaviShankar), India.

Arch Surg. 2011;146(2):179-182. doi:10.1001/archsurg.2010.345
Abstract

Objectives  To evaluate role of magnetic resonance spectroscopy in differentiating benign from malignant follicular nodules.

Design  Prospective study.

Setting  Department of Surgery in collaboration with Department of Radio Diagnosis, Maulana Azad Medical College, Delhi, India.

Patients  Twenty-five patients with a solitary thyroid nodule with follicular etiology.

Interventions  Magnetic resonance spectroscopy was carried out in all the cases, and its findings were compared with the final diagnosis based on histopathological examination of sample obtained at surgery.

Main Outcome Measures  Choline peak detected on MRS.

Results  There were 17 benign cases, 16 follicular adenomas, and 1 colloid goiter. Of the 17 benign cases, only 1 showed choline peak; however, all 8 follicular carcinoma cases showed prominent choline peak. Hence, the sensitivity is 100% while the specificity is 94.11%.

Conclusion  Magnetic resonance spectroscopy may prove to be a sensitive diagnostic tool in differentiating follicular adenomas from carcinomas.

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