[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
January 1, 1929

COLLOID CARCINOMA OF THE COLON AND RECTUM

Author Affiliations

Fellow in Surgery, The Mayo Foundation ROCHESTER, MINN.
From the Division of Surgery, The Mayo Clinic.

Arch Surg. 1929;18(1_PART_I):129-139. doi:10.1001/archsurg.1929.04420010131006
Abstract

The origin and significance of the gelatinous material found in tumors designated colloid carcinoma has long been a subject of interest. Colloid has been described as a product of degeneration taking place in a tumor; it has probably been derived either from epithelial or connective tissue, or both. It is now agreed that it is secretory in origin and derived from the epithelial cells of tumors arising from any of the glandular epithelial structures. Accordingly, Broders1 has defined colloid carcinoma as adenocarcinoma with a tendency to differentiate to the extent that a mucus-like substance is produced, and Robertson2 affirmed that a colloid carcinoma is so-called because it is really a collection of mucus large enough to be appreciable to the eye.

A distinction between mucus and colloid is no longer maintained; they are usually considered identical substances. Wells,3 however, made such a distinction. He submitted a definite chemical composition for

References
1.
Broders, A. C.:  The Grading of Carcinoma ,  Minnesota Med. 8:726, 1925.
2.
Robertson, H. E.:  Unusual Features of Carcinoma ,  Minnesota Med. 8:1, 1925.
3.
Wells, H. G.:  Chemical Pathology; Being a Discussion of General Pathology From the Standpoint of the Chemical Processes Involved , Philadelphia, W. B. Saunders Company, ed. 5, 1925, p. 790.
4.
Delafield, Francis, and Prudden, T. M.:  A textbook of Pathology, with a Final Section on Postmortem Examinations and the Methods of Preserving and Examining Diseased Tissues , New York, William Wood & Company, ed. 13, 1925, p. 54.
5.
Miles, W. E.:  Cancer of the Rectum , London, Harrison and Sons, 1926, p. 72.
6.
Boyd, William:  Surgical Pathology , Philadelphia, W. B. Saunders Company, 1925, p. 200.
7.
McFarland, Joseph:  Surgical Pathology , Philadelphia, P. Blakiston's Son & Company, 1924, p. 377.
8.
Ochsenhirt, N. C.:  The Significance of Mucus-forming Cells in Carcinoma of the Large Intestine and Rectum ,  Surg. Gynec. Obst. 47:32, 1928.
9.
Parham, Duncan:  Colloid Carcinoma ,  Ann. Surg. 77:90, 1923.
10.
Hayes, J. M.:  The Involvement of the Lymph Glands in Carcinoma of the Large Intestine ,  Minnesota Med. 4:653, 1921.
11.
Korte, quoted by Ewing, James:  Neoplastic Diseases, a Textbook on Tumors , Philadelphia, W. B. Saunders Company, ed. 3, 1928, p. 714.
12.
Zinner, quoted by Ewing.
13.
Stinson, J. W.:  Colloid Carcinoma of the Stomach ,  Surg. Gynec. Obst. 46:180, 1928.
14.
Broders, A. C.: Personal communication to the authors.
×