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Article
April 1929

THE EXPERIMENTAL PRODUCTION OF PULMONARY ABSCESS: ETIOLOGIC FACTORS

Author Affiliations

From the Hunterian Laboratory, Johns Hopkins Medical School, and the Laboratory of Surgical Research, Harvard Medical School.

Arch Surg. 1929;18(4):1960-1983. doi:10.1001/archsurg.1929.01140131064074
Abstract

The relationship between chronic infection in the upper respiratory tract and the development of pulmonary abscess is of great experimental interest and equal clinical importance. The recent work from Cutler's laboratory,1 demonstrating that abscesses of the lung may be caused in dogs by embolic processes, does not prove that all abscesses arise in this way. The fact that many of these lesions—such, for instance, as those following epileptiform seizures—cannot be explained on an embolic basis suggests a search for other sources of the infection and directs attention to chronic suppurations in the upper air passages.

In 1923, Kline2 injected material, removed from the mouth and teeth of a man who had died of pulmonary gangrene, into the trachea of rabbits, and obtained small localized areas of pulmonary "gangrene." In 1927, Smith3 reported the development of pulmonary abscesses in mice and rabbits after the introduction into the trachea

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