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Article
August 1947

EFFECT OF ENTEROGASTRONE ON MANN-WILLIAMSON ULCERS IN DOGS

Author Affiliations

DETROIT
From the Research Division, Harper Hospital.

Arch Surg. 1947;55(2):125-129. doi:10.1001/archsurg.1947.01230080130002
Abstract

THIS study has been conducted to evaluate the effect of orally administered enterogastrone on a series of dogs in which jejunal ulcer had been produced by the Mann-Williamson operation. Previous study of a similar nature by others1 has shown that enterogastrone exerts a prophylactic, therapeutic and "immunizing" effect on the experimental Mann-Williamson ulcer when administered parenterally and orally. Recently Ivy and associates2 reported a beneficial effect from enterogastrone in preventing recurrence of ulcer in the treatment of patients.

Enterogastrone is a hormone prepared from small intestine mucosa and exerts an inhibiting (or chalonic) effect on gastric motility and secretion. First prepared by Kosaka and Lim3 from the mucosa of the small intestine of dogs, it was subsequently prepared in purer form by Gray, Bradley and Ivy4 from the mucosa of small intestine of hogs.

METHOD  The routine Mann-Williamson operation, as reported in a separate publication,5

References
1.
Hands, A. P.; Greengard, H.; Preston, F. W.; Fauley, G. B., and Ivy, A. C.:  Prevention of Experimental Gastrojejunal Ulcer by Enterogastrone Therapy ,  Endocrinology 30:905 ( (June) ) 1942.
2.
Greengard, H.; Hands, A. P.; Grossman, M. I., and Ivy, A. C.:  The Preparation of a Subcutaneously Effective Enterogastrone Concentrate ,  Federation Proc. 2:17 ( (March) ) 1943.
3.
Hands, A. P.; Greengard. H.; Fauley, G. B., and Ivy, A. C.:  Prevention of Experimental Gastrojejunal Ulcer by Enterogastrone ,  Federation Proc. 2:18 ( (March) ) 1943.
4.
Ivy, A. C.:  The Prevention of Recurrence of "Peptic" Ulcer: An Experimental Study ,  Gastroenterology 3:443 ( (Dec.) ) 1944.
5.
Greengard, M.; Atkinson, N.; Grossman, M. I., and Ivy, A. C.:  The Effectiveness of Parenterally Administered "Enterogastrone" in the Prophylaxis of Recurrences of Experimental and Clinical Peptic Ulcer ,  Gastroenterology 7:625 ( (Dec.) ) 1946.
6.
Kosaka, T., and Lim, R. K. S.:  Demonstration of the Humoral Agent in Fat Inhibition of Gastric Secretion ,  Proc. Soc. Exper. Biol. & Med. 27:890 ( (June) ) 1930.
7.
Gray, J. S.; Bradley, W. B., and Ivy, A. C.:  On Preparation and Biological Assay of Enterogastrone ,  Am. J. Physiol. 118:463 ( (March) ) 1937.
8.
Saltzstein, H. C.; Sandweiss, D. J.; Hammer, I. M.; Hill, E. J., and Vandenberg, H., Jr.:  Effect Vagotomy on Mann-Williamson Ulcer in Dogs ,  Arch. Surg. , this issue, p. 130.
9.
Beaver, D. C.; Sandweiss, D. J.; Saltzstein, H. C.; Farbman, A. A., and Sanders, A. W.:  Effect of Urine Extracts on Prevention and Healing of Experimental Ulcers in Dogs ,  Am. J. Clin. Path. 12:617 ( (Dec.) ) 1942.
10.
Sandweiss, D. J.; Saltzstein, H. C., and Farbman, A. A.:  Prevention or Healing of Experimental Peptic Ulcer in Mann-Williamson Dogs with Anterior Pituitary-Like Hormone (Antuitrin S): Preliminary Report ,  Am. J. Digest Dis. 5:24 ( (March) ) 1938.
11.
Ivy, A. C.:  The Problem of Peptic Ulcer ,  J. A. M. A. 132:1053 ( (Dec. 28) ) 1946.
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