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August 1969

The Extended Use of Skin Homografts

Author Affiliations

Columbus, Ohio
From the Division of Pediatric Surgery, Department of Surgery, Ohio State University College of Medicine, and the Children's Hospital Research Foundation, Columbus. Dr. O'Neill is now at Louisiana State University School of Medicine, New Orleans.

Arch Surg. 1969;99(2):263-268. doi:10.1001/archsurg.1969.01340140135020

Postmortem skin homografts have been used extensively at this institution in the management of children with burns and with skin losses of other types. The present study was designed with a dual purpose in mind: first, to determine the benefits of temporary homograft skin coverage to burned individuals in conjunction with silver nitrate topical therapy; and second, to investigate the use of homograft in situations other than burns where skin loss is a problem.

In 1953, Brown and his group advocated the use of postmortem homografts as biological dressings in cases of severe burns.1 This method of therapy had first been described by Girdner in 1881 but little attention was given to it.2 Even now, only a few groups around the country have been able to implement this form of therapy, mainly because there is a lack of availability of cadaver skin. Those involved in work with skin

Brown, J.B., et al:  Postmortem Homografts as "Biological Dressings" for Extensive Burns and Denuded Areas ,  Ann Surg 138:618-630 ( (Oct) ) 1953.Crossref
Girdner, J.H.:  Skin Grafting With Grafts Taken From the Dead Subject ,  Med Rec 20:119-120 ( (July) ) 1881.
Zaroff, L.I., et al:  Multiple Uses of Viable Cutaneous Homograft in the Burned Patient ,  Surgery 59:368-372 ( (March) ) 1966.
Smith, B.; Baxter, CF.; and Boles, E.T., Jr.:  A New Technic for Obtaining Fetal Skin for Homografting ,  J Pediat Surg 1:256-259 ( (June) ) 1966.Crossref
Eade, G.G.:  The Relationship Between Granulation Tissue, Bacteria, and Skin Grafts in Burned Patients ,  Plast Reconstr Surg 22:42-55 ( (July) ) 1958.Crossref