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October 1969

Hemorrhagic Shock in Rats: Measured Blood Volumes as the Basis for the Extent of Hemorrhage

Author Affiliations

St. Louis
From the Department of Surgery, Washington University School of Medicine, St. Louis.

Arch Surg. 1969;99(4):484-488. doi:10.1001/archsurg.1969.01340160064015

This study was undertaken in an attempt to establish a method of bleeding rats and autotransfusing the blood removed from them which would be associated with a mortality of near 50%. The use of different combinations of fluids as therapy for hemorrhage in the rat could be assessed optimally, since the likelihood of a given method of treatment being both better or worse than autotransfusing all the blood removed can best be determined when the latter is associated with a mortality of 50%.

A previous study from this laboratory reported a hemorrhagic shock model in the rat which was based upon bleeding to a mean blood pressure of 30 mm Hg for 60 minutes.1 This model was associated with a mortality of only 24% among rats surviving to be treated by returning all the blood removed from them. When the duration of hypotension was lengthened more rats died before

Butcher, H.R., Jr., and Braitberg, A.:  Hemorrhagic Shock in Rats: A Method of Therapeutic Bioassay ,  Arch Surg 98:685-693 ( (June) ) 1969.Crossref
Wang, L.:  Plasma Volume, Cell Volume, Total Blood Volume and Fcells Factor in Normal and Splenectomized Sherman Rat ,  Amer J Physiol 196:188-192 ( (Jan) ) 1959.