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Article
October 1969

Deep Vein Thrombophlebitis: Current Status of Etiology and Treatment

Author Affiliations

New York
From the Institute for Surgical Studies, Department of Surgery, Montefiore Hospital and Medical Center, New York.

Arch Surg. 1969;99(4):489-493. doi:10.1001/archsurg.1969.01340160069016
Abstract

The single most significant conclusion to emerge from examination of the current status of deep vein thrombophlebitis is the rapidly increasing incidence of the disease.

One's first reaction to this observation is that certainly an increasing awareness of the disease must be largely responsible for an apparent overall increase in its incidence. But closer study raises strong suspicion that the finding is not only apparent; it may be real.

Evidence for this deduction cannot be drawn from a simple mathematical tabulation of reported cases. The protean nature of the disease, inconsistent record-keeping, incomplete reporting, and the vagaries of diagnosis make it necessary for meaningful information to be derived from a broad body of evidence which includes studies of sequelae, such as pulmonary embolism and postphlebitic syndrome; from laboratory data which reveal the effects of various drugs on physiologic responses of the vascular system and on coagulation properties of the blood;

References
1.
Torack, R.M.:  The Incidence and Etiology of Pulmonary Infarction in the Absence of Congestive Heart Failure ,  Arch Path 65:574-579 ( (May) ) 1958.
2.
Freiman, D.G.; Suyemoto, J.; and Wessler, S.:  Frequency of Pulmonary Thromboembolism in Man ,  New Eng J Med 272:1278-1280 ( (June 17) ) 1965.Crossref
3.
Morrell, M.T.; Truelove, S.L.; and Barr, A.:  Pulmonary Embolism ,  Brit Med J 2:830-835 ( (Oct 5) ) 1963.Crossref
4.
 Deaths of Women From Thrombosis in England and Wales: Parliament ,  Lancet 1:627, 1967.
5.
Little, J.M., and Loewenthal, J.:  Factors Contributing to a Lowered Mortality from Pulmonary Embolism ,  Surg Gynec Obstet 127:777-782 ( (Oct) ) 1968.
6.
Roach, H.D., and Laufman, H.:  Pulmonary Embolism and Pulmonary Infraction ,  Surg Forum 5:214-219, 1954.
7.
Roach, H.D., and Laufman, H.:  Relationship Between Pulmonary Embolism and Pulmonary Infarction ,  Ann Surg 142:82-91 ( (July) ) 1955.Crossref
8.
Laufman, H.:  Superiority of Heparin in Venous Thromboembolic Disease ,  Surg Clin N Amer 44:195-209 ( (Feb) ) 1964.
9.
VanDam, F.E.; Overkamp, M.; and Maanen, G.:  The Interaction of Drugs , letter to the editor,  Lancet 2:1027, 1966.Crossref
10.
Villavicencio, L., and DeTakats, G.:  Mass Cell Activity Under Various Forms of Stress ,  Surg Forum 8:133-137, 1957.
11.
DeTakats, G.:  Pulmonary Embolism: A Second Look ,  J Internal Cardiovasc Soc 9:3-33 (No. (5) ) 1968.
12.
Matis, P.:  Postoperative Prophylaxis of Thrombosis and Embolism ,  Thromb Diath Haemorrh 5( (suppl) ):86-89, 1961.
13.
Cucinell, S.A., et al:  Drug Interactions in Man: I. Lowering Effect of Phenobarbital on Plasma Levels of Bishydroxycoumarin and Diphenyl Hydantoin ,  Clin Pharmacol Ther 6:420-429 ( (July) -Aug) 1965.
14.
Cucinell, S.A., et al:  The Effect of Chloral Hydrate on Bishydroxycoumarin Metabolism: A Fatal Outcome ,  JAMA 197:366-368 ( (Aug 1) ) 1966.Crossref
15.
DeTakats, G.; Trump, R.A.; and Gilbert, W.C.:  The Effect of Digitalis on the Clotting Mechanism ,  JAMA 125:840-845 ( (July 22) ) 1944.Crossref
16.
Miller, S.P.; Lee, S.L.; and Ritz, N.:  Progestin-Estrogen (SC 11,800) Therapy and the Hemostatic Mechanism: A Controlled Study ,  Metabolism 14(suppl):398-410 ( (March) ) 1965.Crossref
17.
Neistadt, A.; Schwartz, R.W.; and Schwartz, S.I.:  Norethylnodrel With Mestranol and Venous Blood Flow ,  JAMA 198:784-785 ( (Nov 14) ) 1966.Crossref
18.
Drill, V.A., and Calhoun, D.W.:  Oral Contraceptives and Thromboembolic Disease ,  JAMA 206:77-84 ( (Sept 30) ) 1968.Crossref
19.
Winter, I.C.:  The Incidence of Thromboembolism in Enovid Users ,  Metabolism 14(suppl):422-428 ( (March) ) 1965.Crossref
20.
Committee on Safety of Drugs of Great Britain: Report for Year Ended Dec 31, 1967, London: Her Majesty's Stationery Office, 1968.
21.
Gardner, J.H.; Horenstein, S.; and Van den Noort, S.: Oral Contraceptives and Cerebral Ischemia, read before American Association for the Study of Headache, San Francisco, Aug 1968.
22.
Salmon, ML.; Winkelman, J.Z.; and Gay, A.J.:  Neuroophthalmic Sequelae in Users of Oral Contraceptives ,  JAMA 206:85-91 ( (Sent 30) ) 1968.Crossref
23.
Brennan, M.D.; Clarke, A.M.; and Macbeth, W.A.A.G.:  Infarction of the Midgut Associated With Oral Contraceptives: Report of Two Cases ,  New Eng J Med 279:1213-1214 ( (Nov 28) ) 1968.Crossref
24.
Laufman, H.: " The Arteries and Veins ," Davis, L. (ed.):  Christopher's Textbook of Surgery , ed 9, Philadelphia: W.B. Saunders Co., 1968, pp 1249-1314.
25.
Lowenberg, R.I.:  Early Diagnosis of Phlebothrombosis With Aid of a New Clinical Test ,  JAMA 115:1566-1570 ( (Aug 28) ) 1954.Crossref
26.
Homans, J.:  Thrombosis of the Deep Veins of the Lower Leg Causing Pulmonary Embolism ,  New Eng J Med 211:993-997 ( (Nov 29) ) 1934.Crossref
27.
McLachlin, A.K., et al:  Venous Stasis in the Lower Extremities ,  Ann Surg 152:678-685 ( (Oct) ) 1960.Crossref
28.
Laufman, H.:  Ancillary Care in Postphlebitic Syndrome ,  Surg Clin N Amer 39:183-192 ( (Feb) ) 1959.
29.
Wessler, S.; Ballon, J.D.; and Katz, J.H.:  Studies in Intravascular Coagulation: V. A Distinction Between the Anticoagulant and Antithrombotic Effects of Dicoumarol ,  New Eng J Med 256:1223-1225 ( (June 27) ) 1957.Crossref
30.
Sise, H.S., et al:  Relation of Hemorrhage and Thrombosis to Prothrombin During Treatment With Coumarin-Type Anticoagulants ,  New Eng J Med 259:266-271 ( (Aug 7) ) 1958.Crossref
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