[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
April 1976

A Retrospective Study of Regional Perfusion for Melanoma

Author Affiliations

From the Department of Surgery, St John's Hospital and Health Center, Santa Monica, Calif.

Arch Surg. 1976;111(4):410-413. doi:10.1001/archsurg.1976.01360220106017

• Regional perfusion has been utilized in the treatment of accessible melanomas for many years. This series of 245 patients, which encompasses over ten years of experience, is presented to reevaluate the results of regional perfusions in melanomas, and perhaps to redefine the indications for such a procedure. Fifty-nine patients died from three months to over five years following the procedure, and six of the deaths were from diseases other than melanoma. The overall survival in stage I disease was 93%; stage II, 68%; and stage III, 41%. There were no survivors in stage IV. Nearly all of the recurrences and deaths from disease were seen within two years of the perfusion. These results are similar to others, and 10% to 15% better than those of conventional methods. Indications are now more definite, and include most invasive melanomas in an area accessible to perfusion technique, except in very elderly and poor risk patients, those with severe arteriosclerosis in the area concerned, and those with widespread metastases.

(Arch Surg 111:410-413, 1976)

Ryan RF, Winblad JN, Krementz ET, et al:  Treatment of malignant neoplasms with chemotherapeutic agents utilizing a pump oxygenator: Techniques and early results .  Bull Tulane Med Fac 17:133-143, 1958.
Clark WH Jr, From L, Bernardino EA, et al:  The histogenesis and biologic behavior of primary human malignant melanomas of the skin .  Cancer Res 29:705-727, 1969.
McGovern VJ, Mihm MC Jr, Bailly C, et al:  The classification of malignant melanoma and its histologic reporting .  Cancer 32:1446-1457, 1973.Crossref
Rochlin DB:  Isolation perfusion for cancer therapy .  GP 27:91-96, 1963.
Wagner DE, Rochlin DB, Weber AP:  A new approach to radical retroperitoneal, iliac and femoral node dissection .  Arch Surg 103:681-683, 1971.Crossref
Goldsmith HS, Shalla JP, Kim DH:  Prognostic significance of lymph node dissections in treatment of malignant melanoma .  Cancer 26:606-609, 1970.Crossref
Wagner DE, Ramirez G, Weiss AJ, et al:  Combination phase I-II study of imidazole carboxamide (NSC 45388) .  Oncology 26:310-316, 1971.Crossref
McBride CM, Clark RL:  Experience with L-phenylalanine mustard dihydrochloride in isolation perfusion of extremeties for malignant melanoma .  Cancer 28:1293-1296, 1971.Crossref
Krementz ET, Ryan RF, Carter RD, et al:  Chemotherapy by perfusion for malignant melanoma of the limbs , abstracted.  XI Int Cancer Congress 3:538-539, 1974.
Stehlin JS:  Hyperthermic perfusions with chemotherapy for cancers of the extremities , in  Oncology . Chicago, Year Book Medical Publishers Inc, 1970, vol 3, pp 365-366.