JAMA
Preliminary Communication
Caring for the Critically Ill Patient
October 1, 2019
Alpha A. Fowler III, MD; Jonathon D . Truwit , MD; R. Duncan Hite, MD; Peter E. Morris, MD; Christine DeWilde, RN, PhD; Anna Priday, BS, MS; Bernard Fisher, BS, MS; Leroy R. Thacker II, PhD; Ramesh Natarajan, PhD; Donald F. Brophy, PharmD; Robin Sculthorpe, RPh; Rahul Nanchal, MD; Aamer Syed, MD; Jamie Sturgill, PhD; Greg S. Martin, MD, MSc; Jonathan Sevransky, MD, MHS; Markos Kashiouris, MD, MPH; Stella Hamman, RN, MSN; Katherine F. Egan, BSN, RN, CCRC; Andrei Hastings, MD; Wendy Spencer, RN, CPN; Shawnda Tench, BBA, CCRP; Omar Mehkri, MD; James Bindas, MBA; Abhijit Duggal, MD; Jeanette Graf, BS, CCRP; Stephanie Zellner, MS, CCRC; Lynda Yanny, RN, BSN, CCRC; Catherine McPolin, RN, BSN, CCRP; Tonya Hollrith, RT, MR; David Kramer, MD; Charles Ojielo, MD; Tessa Damm, DO; Evan Cassity, MS; Aleksandra Wieliczko, RN; Matthew Halquist, PhD
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JAMA. 2019; 322(13):1261-1270. doi: 10.1001/jama.2019.11825
This randomized clinical trial compares the effects of high-dose vitamin C vs placebo on the incidence of organ failure and biomarkers of inflammation and vascular injury in patients in the intensive care unit (ICU) with sepsis and ARDS.