This exploratory study was conducted to examine trends in cigarette smoking among adults with and without a major depressive episode, substance use disorder, or both and by age, sex, and race and ethnicity.

This cohort study assesses the incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

This study examines breakthrough SARS-CoV-2 infections, hospitalizations, and mortality in March-August 2021, when the Delta variant predominated, among a general US cohort vaccinated with mRNA-1273 or BNT162b2.

This cross-sectional study reports the patterns of methamphetamine use (eg, with or without cocaine, frequency of use, and injected) among participants in the 2015 to 2019 National Survey on Drug Use and Health.

This Viewpoint discusses the Helping to End Addiction Long-term initiative of the National Institutes of Health that was launched in 2018 to provide scientific solutions to the evolving crisis of opioid misuse, addiction, and overdose.

This survey study assesses whether cannabis use and cannabis use disorder are associated with a higher prevalence of suicidality among young adults with or without depression and whether these associations vary by sex.

This cross-sectional study examines the association of time since first substance use with substance use disorders among young people in the US.

This cross-sectional study examines the extent to which methamphetamine overdose deaths vary by sex and race and ethnicity in the US.

This Viewpoint describes the planned Healthy Brain and Child Development Study, which will investigate the associations of parental substance abuse, coronavirus disease 2019 infection, and exposure to health disparities with their children’s health and well-being.

This Viewpoint assesses the different ways treatment and research on psychiatric disorders have shifted because of coronavirus disease 2019 (COVID-19) and suggests what changes should remain after the pandemic.

This study uses National Surveys on Drug Use and Health data to characterize trends in heroin use, heroin use disorder, and heroin injection overall and by age, race, and geographic region.

This study uses National Survey on Drug Use and Health data to examine prevalence and frequency of medical and nonmedical cannabis use among pregnant and nonpregnant women between 2013 and 2017.

This narrative review addresses the rewarding and analgesic effects of opioids, the epidemiology of the opioid crisis, and interventions used to treat and prevent opioid use disorder.

This case-control study examines the real-time changes and associations between physical activity, sleep patterns, and energy and mood levels in people with and those without bipolar or depressive disorder.

This Viewpoint discusses the National Institutes of Health’s Helping to End Addiction Long-term, an interdisciplinary program aimed at advancing addiction and pain research in the United States.