This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening and interventions to prevent dental caries in children summarizes published evidence on the benefits and harms of screening and interventions provided by primary care clinicians to prevent dental caries in children younger than 5 years.

This 2021 Recommendation Statement from the US Preventive Services Task Force recommends that primary care clinicians prescribe oral fluoride supplementation starting at age 6 months for children whose water supply is deficient in fluoride (B recommendation) and apply fluoride varnish to the primary teeth of all children starting at the age of primary tooth eruption (B recommendation) and concludes that current evidence is insufficient to assess the benefits and harms of routine primary care dental caries screening in children younger than 5 years (I statement).

This cross-sectional study examines the utility of untargeted metabolomics as a primary screening tool for inborn errors of metabolism by comparing the diagnostic rate of clinical metabolomics with the recommended traditional metabolic screening approach.

This systematic review and meta-analysis assesses the association of nonmedicated control substances in randomized clinical trials with disease outcomes in patients diagnosed with chronic rhinosinusitis.