This Viewpoint discusses the promise of personalized or precision medicine compared with its achievements to date.
This 2021 US Preventive Services Task Force Recommendation Statement recommends that clinicians ask all adults about tobacco use, advise them to stop using tobacco, and provide behavioral interventions and pharmacotherapy for cessation (A recommendation) and concludes that evidence is insufficient to assess the benefits and harms of tobacco cessation pharmacotherapy in pregnant persons and e- cigarettes for tobacco cessation in any adult (I statement).
This nonrandomized controlled intervention study compared the effect of matched sibling donor hematopoietic stem cell transplantation (HSCT) vs standard care comprising transfusions and hydroxyurea on transcranial Doppler velocities, a measure of cerebral vasculopathy, at 1 year in children with sickle cell anemia requiring chronic transfusion.
This study characterizes use of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis who do not require supplemental oxygen in Canadian and US hospitals.
This study reports 7-year outcomes data for patients with uveitis randomized in the Multicenter Uveitis Steroid Treatment trial to receive an intravitreous fluocinolone acetonide implant vs prednisone or other immunosuppressant therapy.
This multicenter cohort study describes a novel clinical risk score developed among children presenting to the emergency department with concussion and head injury within the previous 48 hours to stratify risk of persistent postconcussion symptoms at 28 days.
In a randomized trial evaluating the effects of a communication skills intervention for internal medicine and nurse practitioner trainees, Curtis and coauthors measured patient- and family-reported outcomes including quality of communication. In an Editorial, Verghese and Chi discuss the findings in the context of improving communication with patients.
This 2019 Recommendation Statement from the US Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for elevated blood lead levels in asymptomatic children (I statement) and asymptomatic pregnant persons (I statement).
Dewey and colleagues found that depending on the sequencing platform used, there was incomplete coverage of inherited disease genes, low reproducibility of potentially clinically significant genetic variation, and uncertainty about clinically reportable findings.
This narrative review summarizes recent advances in the prevention, diagnosis, and treatment of delirium and highlights critical areas for future research.
This 2018 Recommendation Statement from the US Preventive Services Task Force recommends screening for unhealthy alcohol use in primary care settings in adults, including pregnant women, and providing brief behavioral counseling to reduce unhealthy alcohol use (B recommendation) and concludes that evidence is insufficient to assess balance of benefits and harms of screening and counseling for alcohol use in primary care settings in adolescents (I statement).
This systematic review to support the 2019 US Preventive Services Task Force Recommendation Statement on screening for elevated blood lead levels in childhood and pregnancy summarizes published evidence on the benefits and harms of screening and intervention for elevated blood lead levels in pregnant women and children 5 years and younger in the primary care setting.
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