This Arts and Medicine feature reviews The Mould That Changed the World, a musical about the history of penicillin that uses fringe set design, eccentric staging, and quirky lyrics to teach audiences the importance of antimicrobial stewardship.

This Viewpoint discusses the benefits of expanded access research, the usefulness of expanded access data, the issues surrounding cost and transparency, and the adjusted role of institutional review boards.

This JAMA Insights summarizes the prevalence of keratitis and its association with improper use of contact lenses; and summarizes the types, pathology, diagnosis, and treatment of keratitis.

A woman who had immigrated from Guatemala 1 year prior developed headache, photophobia, vomiting, somnolence, and confusion but no focal neurologic deficits. Brain CT showed ventriculomegaly, hydrocephalus, and cerebral edema, while brain MRI showed a nonenhancing lesion obstructing the aqueduct of Sylvius that moved to the fourth ventricle with hydrocephalus resolution on repeat imaging 5 days later. What is the diagnosis and what would you do next?

This randomized clinical trial compares use of a school-wide integrated pest management (IPM) program vs use of high-efficiency particulate air (HEPA) filter purifiers in the classrooms for students with active asthma attending urban elementary schools who were randomized to IPM by school and HEPA filter purifiers by classroom.

This Viewpoint proposes measures the incoming Biden administration can take to increase access to health insurance coverage under the Affordable Care Act (ACA) and Medicaid, including limiting short-term ACA coverage provisions, rolling back state Medicaid waivers, and simplifying Medicaid eligibility.

This guideline summarizes updated recommendations for management of asthma in adolescents and adults, focusing on evidence for use of inhaled corticosteroids (ICSs), add-on long-acting muscarinic antagonists (LAMAs), fractional exhaled nitric oxide (FeNO) testing, indoor allergen mitigation, immunotherapy, and evidence against use of bronchial thermoplasty.

This Arts and Medicine feature presents “Outer Space”, a neo-punk song written, played, and produced by a practicing neurogenetics psychiatrist to honor the brilliance of people with autism spectrum disorder and their families.

A woman from the Southeastern US with a history of smoking, poorly controlled diabetes, and inhalational medical marijuana use had 4 months of productive cough, weight loss, subjective fevers, 3 days of worsening chest pain, and a large right upper lobe cavitary mass on chest CT unresponsive to antibiotics. AFB smear and GeneXpert MTB/RIF testing were negative; she developed a right-sided tension pneumothorax after intubation for hypoxemia, and chest tube placement yielded charcoal-colored pleural fluid. What is the diagnosis and what would you do next?